Journal: Frontiers in Human Neuroscience

Article Title: To assure aviation safety: the pilot fatigue detection based on short-term multimodal physiological signals

doi: 10.3389/fnhum.2026.1743936

Figure Lengend Snippet: Schematic overview of the proposed pilot fatigue detection framework. The pipeline consists of three sequential stages: (1) Signal preprocessing and segmentation of EEG/ECG data, (2) Pivotal feature selection using ANOVA and EEG channel selection using SVM-based AUC ranking, and (3) Final fatigue classification using the XGBoost model. With permission from .

Article Snippet: Pilot ECG signals were collected using a single-channel Mi-Rhythm Holter ECG recorder (Shenzhen Ruikang Hongye Technology Development Co., Ltd., China) at a sampling rate of 250 Hz.

Techniques: Selection

Journal: Frontiers in Human Neuroscience

Article Title: To assure aviation safety: the pilot fatigue detection based on short-term multimodal physiological signals

doi: 10.3389/fnhum.2026.1743936

Figure Lengend Snippet: Illustration of the ECG device. The single-channel Mi-Rhythm Holter recorder includes (a) the host unit, (b) a protective silicone sleeve, and (c) disposable electrode patches. This compact design allows for unobtrusive recording of cardiac activity.

Article Snippet: Pilot ECG signals were collected using a single-channel Mi-Rhythm Holter ECG recorder (Shenzhen Ruikang Hongye Technology Development Co., Ltd., China) at a sampling rate of 250 Hz.

Techniques: Activity Assay

Journal: Frontiers in Human Neuroscience

Article Title: To assure aviation safety: the pilot fatigue detection based on short-term multimodal physiological signals

doi: 10.3389/fnhum.2026.1743936

Figure Lengend Snippet: Visualization of the EEG and ECG signal preprocessing and segmentation. Both EEG and ECG signals are filtered (0.5–30 Hz) and segmented into 2-s epochs with a 50% overlap using a sliding window technique. This synchronized segmentation ensures that each data sample contains aligned multimodal information.

Article Snippet: Pilot ECG signals were collected using a single-channel Mi-Rhythm Holter ECG recorder (Shenzhen Ruikang Hongye Technology Development Co., Ltd., China) at a sampling rate of 250 Hz.

Techniques:

Journal: Frontiers in Human Neuroscience

Article Title: To assure aviation safety: the pilot fatigue detection based on short-term multimodal physiological signals

doi: 10.3389/fnhum.2026.1743936

Figure Lengend Snippet: Comparison of single-channel SVM classification performance (AUC) utilizing features from single vs. fused frequency bands. The bar chart compares the AUC of single-channel SVM classifiers using features from individual frequency bands versus fused features from all 4 bands (red bars). Data are obtained based on 10-fold cross-clip cross-validation. Adapted with permission from .

Article Snippet: Pilot ECG signals were collected using a single-channel Mi-Rhythm Holter ECG recorder (Shenzhen Ruikang Hongye Technology Development Co., Ltd., China) at a sampling rate of 250 Hz.

Techniques: Comparison, Biomarker Discovery

Journal: Antioxidants

Article Title: Limitations of Ferroptosis Inhibitors on the Doxorubicin-Induced Cardiotoxicity

doi: 10.3390/antiox15010027

Figure Lengend Snippet: Ferroptosis inhibitors fail to rescue cardiac dysfunction. ( A ) Brief schedule of in vivo experiment. C57BL/6J mice were treated with ferrostatin-1 (Fer-1) or liproxstatin-1 (Lip-1) 24 h before doxorubicin injection and were dosed every 24 h. A single dose of doxorubicin was administered intraperitoneally once on day 1. Experimental groups: Vehicle, DOX (20 mg/kg, i.p.), DOX + Fer-1 (2 mg/kg, i.p.), and DOX + Lip-1 (10 mg/kg, i.p.) ( B ) The survival graph of mice from different groups was shown by Kaplan–Meier survival analysis. ( C ) Three days after intraperitoneal injection of doxorubicin, the mouse cardiac function was analyzed with echocardiography. The echocardiography data showed decreased fractional shortening and ejection fraction in mice treated with doxorubicin and Fer-1 or Lip-1. Survival rate, n = 5 per group; ECG, n = 5 per group. ( D ) Bar graph representation of the heart weight to body weight ratio of mice. ( E ) 3,3’-Diaminobenzidine immunohistochemical staining for 4-hydroxynonenal (4-HNE) in the mouse heart tissue; scale bars, 200 µm (left panel). Quantification of 4-HNE-specific 3,3’-Diaminobenzidine staining (right panel). ( F ) Bar graph representation of the N-terminal pro B-type natriuretic peptide (NT-proBNP) of mice. ( G ) Masson’s trichrome and Sirius red staining of fibrosis in the mouse heart (left panel) and quantification (right panel). ( H ) Western blot of ferroptosis cell death markers in mouse heart tissues treated with doxorubicin and Fer-1 or Lip-1. heart weight to body weight, n = 3 per group; 4-HNE, n = 3 per group; NT-proBNP, n = 7 per group; Masson’s trichrome and Sirius red, n = 3 per group; Western blots, n = 3 per group. Data are presented as mean ± S.D., where n represents the number of individual mice per group. Statistical significance was determined by one-way ANOVA followed by Sidak’s multiple comparison test for panels ( C , F ), and the Kruskal–Wallis test was used for panels ( D , E , G ), ns, no significance, * p < 0.05, ** p < 0.01, *** p < 0.005, **** p < 0.001.

Article Snippet: ECG recordings were conducted for 22 days, with each mouse housed individually in a cage equipped with a receiver (RPC-1, Data Sciences International).

Techniques: In Vivo, Injection, Immunohistochemical staining, Staining, Western Blot, Comparison

Journal: Antioxidants

Article Title: Limitations of Ferroptosis Inhibitors on the Doxorubicin-Induced Cardiotoxicity

doi: 10.3390/antiox15010027

Figure Lengend Snippet: Ferroptosis inhibitors do not alleviate doxorubicin-induced arrhythmic changes in mice. ( A ) Electrocardiogram (ECG) traces recorded on day 1 after DOX administration with or without ferroptosis inhibitors, showing various arrhythmic events, including tachyarrhythmia, frequent premature ventricular contractions, irregular rhythm, and cardiac arrest. Red arrows indicate representative arrhythmic events, including premature ventricular contractions and irregular R−R intervals. ( B ) ECG traces recorded on day 21, demonstrating the progression of arrhythmic changes, including atrioventricular (AV) block and bradycardia with AV block, indicated by red arrows. n = 4 per group. Data are presented as mean ± S.D., where n represents the number of individual mice per group. Statistical significance was determined by one-way ANOVA followed by Sidak’s multiple comparison test.

Article Snippet: ECG recordings were conducted for 22 days, with each mouse housed individually in a cage equipped with a receiver (RPC-1, Data Sciences International).

Techniques: Blocking Assay, Comparison

Journal: Frontiers in Physiology

Article Title: A comparative study on L-thyroxine treatment and sesame oil supplementation in experimentally induced hypothyroidism in rats

doi: 10.3389/fphys.2025.1606528

Figure Lengend Snippet: ECG changes and cardiac enzymes changes in the different studied groups: a: significance from the control group by LSD at p ≤ 0.05. b: Significance from the hypothyroid group by LSD at p ≤ 0.05. c: Significance from the L-thyroxine-treated hypothyroid group by LSD at p ≤ 0.05. d: Significance from the sesame oil-treated hypothyroid group by LSD at p ≤ 0.05.

Article Snippet: When the stage of surgical anesthesia was reached, an ECG recording was performed using the ECG recorder Cardimax FX-2111 (Fukuda Denshi Co., Ltd., Japan).

Techniques: Control